Balancing Mechanism study of adult stem cells

Adult stem cells as a type of cells with specific differentiation potential, widespread presence of various tissues and organs of multicellular organisms, and with the maintenance of tissue homeostasis and regeneration functions. In a stable environment, adult stem cells to maintain tissue homeostasis in two ways: one way is asymmetric division, stem cells when each division, one daughter cell remains a stem cell while the other daughter cells differentiate into the state. This approach is known to maintain the balance of asymmetric cell, the other is symmetrical split mode, when each division, stem cell fate of two identical daughter cells or are differentiated cells. When split into two differentiated cell ratio and split into two stem cells in the same proportion, the number of stem cells in the population is still balanced. Such a dynamic equilibrium is known as asymmetric groups.

Previous studies have found that, from invertebrates to vertebrates, used by different organizations both conservative balanced mode on the one hand, there are differences in the other side. Previous studies found that invertebrates are mostly used asymmetric cell mode, and vertebrate populations organization prefers asymmetric mode. General experimental methods such evidence in stem cell lineage tracer. Because of the general lack of robust specific adult stem cell markers, and the need to build fixed transgenic recombination system and long-tracer, so this method has significant limitations.

Population genetics, evolutionary biology as a core branch, for the study of the evolution of the cell population provides accumulate a lot of theories and methodologies. In the cell population, stem cell division patterns will update the different ways the cell population have a major impact, and then HA ELISA Kit will have ancestral relationships between different forms of cells. Such genealogical relationships and human populations ancestral relationship is very similar.

Beijing genome sequencing data the researchers used mice of different ages unicellular intestinal epithelial cells, through coalescent model analyzes and inference. The study found that young mice of intestinal stem cells is mostly first cell asymmetric mode, and adult mice (340 days) of intestinal stem cells is the second group is completely asymmetric way. The first study found that adult stem cells to maintain tissue homeostasis splitting pattern is characterized by a gradual evolution with age, which is an entity organized vertebrate first observed this phenomenon, organizational renewal for the study of vertebrate has very important significance. The study combines the single-cell sequencing, developmental biology, population genetics.

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