Biokit's Blog (23)

Carbohydrate microarray experimental guidance

After years of exploration, scientists have mastered the basic biological features of many sugar molecules, but compared to DNA and protein, not enough for us to understand these molecules, however, due to the complex structure of sugar, in order to build This molecule is very difficult, and the DNA is different from the glycoside is almost impossible for cloning and amplification, and therefore the number is limited. Sugar chips by a small amount and more types of natural or synthetic…

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Added by biokit on April 9, 2015 at 1:16am — No Comments

Conducive to nerve regeneration extracellular matrix

Recently, Professor Lin Yiwen China Taiwan China Pharmaceutical University, suggested that many researchers have attempted to combine the concept of nerve regeneration and nerve recovery into another treatment of neurodegenerative diseases. To solve this problem, we need to know more about how neurons express in a natural environment, because most of the cells are surrounded by brain tissue in an organ or a different hardness range of fat and cartilage.…

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Added by biokit on April 7, 2015 at 11:14pm — No Comments

Reverse evolution of cancer

Researchers from an evolutionary perspective to understand the development of tumors, the individual cells develop into tumors in the process as a short-term evolution of cellular events. The article points out, multicellular organisms have evolved in order to maintain the multi-cell genetics some restrictions. In theory, the cancer may be the result of such restrictions occur due to the collapse.

Researchers through the complete life cycle of a transplanted tumor to show people,…

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Added by biokit on March 31, 2015 at 11:23pm — No Comments

Balancing Mechanism study of adult stem cells

Adult stem cells as a type of cells with specific differentiation potential, widespread presence of various tissues and organs of multicellular organisms, and with the maintenance of tissue homeostasis and regeneration functions. In a stable environment, adult stem cells to maintain tissue homeostasis in two ways: one way is asymmetric division, stem cells when each division, one daughter cell remains a stem cell while the other daughter cells differentiate into the state. This approach is…

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Added by biokit on March 30, 2015 at 11:06pm — No Comments

The human embryonic germ cells and gene editing

In addition to the non-reproductive potential of human cell lines, scientists should not even try to human germ cells for gene editing. But the article also acknowledged for germ cell gene editing or explain things like infertility and other basic scientific problems. And edited by a single gene embryonic cells can also help elaborate the key issues early human embryonic development.

However, germ cell gene editing will be accompanied by a number of negative effects can not be…

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Added by biokit on March 25, 2015 at 10:53pm — No Comments

Secret weapon against the bacterial antibiotic

EHEC can cause more severe symptoms, in addition to diarrhea can also lead to serious complications and sequelae, such as hemorrhagic colitis and hemolytic uremic syndrome, about 3-75% of cases, death. In the survivors, 30% display chronic renal failure, hypertension and nervous system damage. Both pathogenic organisms have two major virulence characteristics areas show the difference: EHEC can generate Shiga toxin, but EPEC can not; EHEC and EPEC settlers settled in the large intestine to…

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Added by biokit on March 23, 2015 at 11:26pm — No Comments

Researcher using next-generation sequencing to rapidly identify pathogens

He calls himself the bug hunter, but the target of his work consists of viruses that can only be found and identified with special methods and instruments. Benjamin Hause, an assistant research professor at the Kansas State Veterinary Diagnostic Laboratory at Kansas State University, recently published an article about one of his discoveries, porcine enterovirus G, which is an important find in the United States.

"We had isolated a virus in cells, but didn't know what it was," Hause…

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Added by biokit on March 19, 2015 at 4:42am — No Comments

CTLA-4 antibody Progress

CTLA-4 gene is located on the long arm of chromosome 2 33 band (2q33), mainly expressed on activated T cells, collaboration and stimulate T cell surface receptor molecule (CD28) with a high degree of homology. CTLA-4 and CD28 are both members of the immunoglobulin superfamily, both with the same ligand CD86 (B7-2) and CD80 (B7-1) combined. In contrast with the function of CD28, CTLA-4 and B7 molecules upon binding inhibition of T cell activation.

CTLA4 and B7 molecules with high…

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Added by biokit on March 17, 2015 at 4:10am — No Comments

Next-generation sequencing technology in molecular diagnosis

Many research institutes, experts and industry insiders Qiju Tai states. From the deputy director of the Institute of Pediatrics, School of Medicine, Shanghai Jiaotong University Professor of Translational Medicine Fu Qihua application in molecular diagnosis of genetic diseases for next-generation sequencing technologies are analyzed.

Next-generation sequencing technology (NGS) is revolutionizing the entire ecology of biomedical research, it has been widely used not only in the field…

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Added by biokit on March 13, 2015 at 4:46am — No Comments

Mammalian Cell Expression System

High expression level, easy operation, short circle, low cost and easy cultivation with high density and large-scale are the advantages of prokaryotic expression system. To complete antibody and glycoprotein biological drugs, the synthesis, secretion ,bio-activation, stability in vivo and immunogenicity of the expression product are often affected by the folding of the peptides , the forming of disulfide bond , the type of glycosylation and whether has glycosylation or not. The product is…

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Added by biokit on March 5, 2015 at 2:38am — No Comments

Young people will suffer from Alzheimer's disease

Recently, published in the journal Brain internationally renowned research paper, the researchers from Northwestern University study for the first time by 20-year-olds in the brain neurons found in the accumulation of amyloid protein, amyloid is An accumulation of abnormal proteins in the brain, which is the main indicator of Alzheimer's disease.

The researchers believe that this study is the first to reveal the young people there will accumulate in the brain of amyloid, but the…

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Added by biokit on March 3, 2015 at 4:17am — No Comments

Whole genome sequencing can predict the effect of chemotherapy in pancreatic cancer

Recently, the international top journals Nature published a new study progress of Australian scientists, they through whole genome sequencing and analysis of CNV in patients with pancreatic cancer redefined pancreatic cancer mutations map.

Pancreatic cancer remains one of the highest death rate of malignant tumor, a major burden is to human health. The researchers studied 100 pancreatic ductal adenocarcinoma (PDAC) patients for whole genome sequencing and copy number variation (CNV)…

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Added by biokit on February 28, 2015 at 2:47am — No Comments

Gastric bypass surgery mechanism behind diabetes

Recently, Lund University research team has clarified why gastric bypass surgery often can quickly relieve the symptoms of diabetes. 85% of type 2 diabetic patients underwent gastric bypass surgery within a few days will be able to recover from the disease, blood glucose levels return to normal.

Previous studies of the samples underwent gastric bypass surgery patients before and after treatment were analyzed, but the result is often incorrect. Because they may not recognize the effect…

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Added by biokit on February 13, 2015 at 3:17am — No Comments

Guangzhou biological hospital had stated KLF4 apoptosis induced T-ALL Expression Mechanisms

KLF4 (Kruppel-like factor 4) induces tumorigenesis, but also can inhibit tumor growth in a tissue-dependent conditions. However, KLF4 role and mechanism of malignant tumors of the blood is still not clear. Li Research Group induce Jurkat T-ALL cell lines and primary leukemia cells in patients with KLF4 overexpression combined immunodeficient mouse xenograft model in vivo validation, explore the in vitro and in vivo function of KLF4 in T-ALL cells, and through genomic RNA-Seq analysis KLF4 in…

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Added by biokit on February 10, 2015 at 3:51am — No Comments

Scientists have discovered that Mycobacterium tuberculosis inhibition of host innate immune mechanism

Institute of Microbiology of the Chinese Academy of Sciences, a study team and revealed Mycobacterium tuberculosis (Mtb) in secretory tyrosine phosphatases (PtpA) by inhibiting the host innate immune signaling pathways to promote the survival of Mycobacterium tuberculosis in macrophages. The researchers also found that Mycobacterium tuberculosis can take advantage of host cells thereby inhibiting ubiquitin molecules innate host immune function.

Innate immunity is the body's resistance…

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Added by biokit on February 5, 2015 at 4:16am — No Comments

Mexican scientists use optical technology to detect cell

Mexican Institute of Biomedical UNAM carried out a "high-speed biological detection technology" project, the detector of the invention to combine the characteristics of the laser principle analysis of cell and cell fluorescence analysis. When the antibody molecule labeled by a fluorescent substance bound to the phosphor, the phosphor absorbs and releases light of varying wavelengths, and then to capture the laser light into the meter. Each cell in the different proteins have different…

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Added by biokit on January 29, 2015 at 2:39am — No Comments

A substance that can help cultivate crops resistant

Kobe University research team found that the main component of the blade odor "2-hexenal" some vegetables can improve heat resistance. This helps to foster conditions in the global warming heat crops.

Many plants have the potential to withstand four or five degrees Celsius, but at room temperature, which endure high temperature shutdown mechanism in the state. If the temperature rises sharply, plants respond to Rat Insulin-like growth factor 1 ELISA Kit…

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Added by biokit on January 28, 2015 at 3:44am — No Comments

Application BCL-2 inhibitors in treatment of acute myeloid leukemia

Recently, scientists from Stanford University School of Medicine in the international journal nature medicine online published their latest research advances them through large-scale RNAi screening methods found in acute myeloid leukemia, IDH1R132H against apoptotic gene mutation BCL- 2 has a strong dependence, with BCL-2 inhibitor treatment, will lead to apoptosis of cells containing the mutant IDH1R132H more likely.…

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Added by biokit on January 28, 2015 at 2:29am — No Comments

Leptin and insulin action on POMC neurons promote browning of white fat

Recently, from Monash University, Australia's Tony Tiganis cell in top international journals published their leptin and insulin action on POMC neurons in the promotion of white fat brown-related research. Article first prove synergy leptin and insulin can drive in POMC neurons of white fat brown in order to maintain the body's energy balance.

The researchers noted that leptin is secreted by fat cells is an important factor of fat for energy balance and weight control plays an…

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Added by biokit on January 20, 2015 at 3:58am — No Comments

Periventricular gray matter in the pathogenesis of ectopic

Periventricular gray matter heterotopia are a class of cortical malformations, showed neurons appear gathered in periventricular abnormalities. Periventricular gray matter induced ectopic molecular mechanisms are still not clear. In this study, Xiongzhi Qi research team found a gene associated with Down syndrome, calcineurin regulatory protein 1, it plays an important role in the rat cortex during development. Using short hairpin RNA expression Rcan1 reduced radial migration will affect the…

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Added by biokit on January 20, 2015 at 3:25am — No Comments

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