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beautybigbang posted a blog post

An overview of antibody structure and fragment

Conventional antibodyConventional antibodies or fully sized antibodies are glycoproteins called immunoglobulins that are produced by the reaction of plasma cells with foreign molecules or antigens. The most basic function of antibodies is to bind specific antigens and stimulate immune responses to protect the body from infection. Antibodies include several subtypes, and here IgG and IgM subtypes are mainly described. Antibodies…See More
23 hours ago
beautybigbang posted a blog post

A detailed introduction to recombinant protein drugs (Part Three)

2.Technical methods for expressing host cell construction(1). Target gene acquisition1). Primer synthesis technologyPrimer refers to a single-stranded DNA molecule that can be covalently bound to a nucleic acid template at the beginning of nucleotide polymerization and function as a replication extension origin. The synthesis of primers uses solid phase DNA synthesis technology. The specific technical process is as follows:The nucleotide attached to the controlled pore glass is reacted with…See More
Thursday
beautybigbang posted a blog post

What are tumor markers and how important are them?

First, what is the tumor marker?Tumor cells release certain substances, such as hormones, enzymes and antigens, which may be metabolites of tumor cells. These substances may be present in tumor cells or may be present in the body fluids of patients through the immunological properties of these substances to judge and identify the tumor. The metabolism of tumor cells is different from that of normal cells, so there will be some changes in the humoral environment of tumor patients. This change…See More
Nov 12
beautybigbang posted a blog post

The Introduction of Disialic Ganglioside (GD)2

3F8 antibodyRecombinant Mouse Antibody (3F8 antibody) is capable of binding to GD2 ganglioside, expressed in Chinese Hamster Ovary cells (CHO). It is a murine IgG3 with a moderate affinity for GD2.What is GD2?In 1935, researchers first discovered a new substance, ganglioside, in the Ganglionzellen cells of the gray matter of the brain. There are many kinds of gangliosides. So far, more than 70 kinds of…See More
Oct 31
beautybigbang posted a blog post

The history of autoimmune disease and animal models (part three)

Rheumatoid arthritis Rheumatoid arthritis is considered to be a clinical syndrome spanning several disease subsets. These different subsets entail several inflammatory cascades, which all lead to a final common pathway in which persistent synovial inflammation and associated damage to articular cartilage and underlying bone are present. One key inflammatory cascade involves overproduction and overexpression of…See More
Oct 30
beautybigbang posted a blog post

Introduction to the physical properties of metal powder

The physical properties of metal powder are mainly reflected in the following aspects:1.Theparticle size and compositionThe particle size and composition of the metal powder depends on the preparation conditions of the metal powder, and it has a great influence on the behavior of the metal powder during pressing and sintering as well as the properties of the product.Using particle diameters to characterize metal powder particle…See More
Oct 24
beautybigbang posted a blog post

Comprehensive Analysis of Targeted Drugs for Lung Cancer

Incidence of lung cancerLung cancer has the highest incidence of cancer in the world. According to WHO’ statistics, there are an estimated 18.1 million new cancer patients worldwide in 2018, of which lung cancer accounts for about 2.094 million, accounting for 11.6%. Lung cancer treatment drugs are also the focus of research and development of major pharmaceutical enterprises. From earlier afatinib and gefitinib to now osimertinib and PD-1/L1 inhibitors, it can be found that although these…See More
Oct 23
beautybigbang posted a blog post

An overview of mass spectrometry

OverviewThe development history of mass spectrometry (MS) dates back to the beginning of the 20th century. The original mass spectrometer was mainly used to determine the atomic mass of elements or isotopes. With the development of ion optics theory, mass spectrometers have been continuously improved, and their applications are constantly changing. It has been widely used in the determination of inorganic compounds and organic compounds in the late 1950s. After the 1980s, the development of new…See More
Oct 20
beautybigbang posted a blog post

Main Methods for Determination of Polymer Molecular Weight

Molecular weight and molecular weight distribution of polymers are one of the most basic data for studying the properties of polymers and polymer materials. It involves the mechanical properties of polymer materials and products, the rheological properties of polymers, the processing properties of polymers and the selection of processing conditions. It is also one of the basic data needed in the field of polymer chemistry and polymer physics for the study of specific polymeric reactions and the…See More
Oct 17
beautybigbang posted a blog post

Application of whole exome sequencing in diseases

Background and overviewAn exome is the sum of all protein coding sequences (ie, exons) on the genomic DNA of an individual. The human exome sequence accounts for only 1% of the entire human genome sequence, about 30 Mb, including about 180,000 exons. It is estimated that 85% of the human pathogenic mutations are located in the 1% protein coding sequence. Therefore, the exome group of patients with various diseases is sequenced and analyzed, and the "coding sequence", which is the most relevant…See More
Oct 14
beautybigbang posted a blog post

An Overview of Coagulation Factor

Coagulation factors are various protein components involved in the blood coagulation process. Its physiological role is to activate when blood vessels bleed, stick to platelets and fill the leaks on the blood vessels. This process is called coagulation. The entire coagulation process can be roughly divided into two phases, activation of prothrombin and formation of gelatinous fibrin. They are partly produced by the liver. Can be inhibited by coumarin. For the uniform naming, the World Health…See More
Oct 11
beautybigbang posted a blog post

Creative BioMart--A Leading Global Supplier of Protein Products and Protein Services

Creative BioMart is a science driven company based in the US yet radiated worldwide. Over the past decade, Creative Biomart set off from a small manufacturer of proteins and enzymes for academic institutes and bio-tech companies, and now it has become one of the most trustworthy brands in the protein market. Featured Products:Based on its own advanced protein engineering and expression platform, Creative BioMart is capable to provide a wide range of high quality protein products for research…See More
Sep 27
beautybigbang posted a blog post

An overview of 18 kinds of amino acids and their efficacy (part II)

Isoleucine(ILE)(1). It can maintain the body balance, treat mental disorders(2). Increase appetite and anti-anemia(3). Present physical exhaustion, coma and other symptoms when lackingTryptophan (TRY)(1). Promote the synthesis of hemoglobin(2). Prevent ecdysis(3). Promote growth, increase appetite(4). Its sweetness is 35 times that of sugar, which is good for the production of low-sugar foods for diabetics and obese patients.…See More
Sep 26
beautybigbang posted a blog post

A list of Creative Biomart’s Protein Products and Protein Manufacturing Solutions

Brief IntroductionCreative Biomart is a world leader in protein and enzymes related products and technology. Founded in 2005, which is headquartered in Shirley, New York. Creative Biomart is dedicated to the offering of high quality protein products and efficient protein manufacturing techniques, including Protein Engineering Services, Protein Extraction Services, Protein Expression and Purification Services as well as Membrane Protein Services and protein labeling etc. For recent years,…See More
Sep 24
beautybigbang posted a blog post

The History Development and Future Challenges of Bispecific Antibodies

Bispecific antibodies (bsAbs) combine specificities of two antibodies and simultaneously address different antigens or epitopes. BsAbs with “two-target” functionality can interfere with multiple surface receptors or ligands associated.Development history of three generations of bispecific antibodiesThe advent of hybridoma technology in the 1970s reminded people whether the same antibody could be used to target two different targets, namely …See More
Sep 22
beautybigbang posted a blog post

Guide For Short Tandem Repeats And Its Implementation Importance

Brief Introduction to Short Tandem RepeatsMicrosatellite DNA, also known as short tandem repeats (STR) or simple repeat sequences (SRS or SSR), is widely found in prokaryotic and eukaryotic genomes, consisting of a unit of two to thirteen nucleotides repeated hundreds of times in a row on the DNA strand which is about 5% of the eukaryotic genome, the basic unit (core sequence) is 1-6bp. The most common of…See More
Sep 21

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Beautybigbang's Blog

An overview of antibody structure and fragment

Posted on November 18, 2019 at 8:46am 0 Comments

Conventional antibody

Conventional antibodies or fully sized antibodies are glycoproteins called immunoglobulins that are produced by the reaction of plasma cells with foreign molecules or antigens. The most basic function of antibodies is to bind specific antigens and stimulate immune responses to protect the body from infection. Antibodies include several subtypes, and here IgG and IgM…

Continue

A detailed introduction to recombinant protein drugs (Part Three)

Posted on November 14, 2019 at 8:15am 0 Comments

  1. 2.Technical methods for expressing host cell construction

(1). Target gene acquisition

1). Primer synthesis technology

Primer refers to a single-stranded DNA molecule that can be covalently…

Continue

What are tumor markers and how important are them?

Posted on November 12, 2019 at 7:52am 0 Comments

First, what is the tumor marker?

Tumor cells release certain substances, such as hormones, enzymes and antigens, which may be metabolites of tumor cells. These substances may be present in tumor cells or may be present in the body fluids of patients through the immunological properties of these substances to judge and identify the tumor. The metabolism of tumor cells is different from that of normal cells, so there will be some changes in the…

Continue

The Introduction of Disialic Ganglioside (GD)2

Posted on October 31, 2019 at 3:03am 0 Comments

3F8 antibody

Recombinant Mouse Antibody (3F8 antibody) is capable of binding to GD2 ganglioside, expressed in Chinese Hamster Ovary cells (CHO). It is a murine IgG3 with a moderate affinity for GD2.

What is GD2?

In 1935, researchers first discovered a new substance, ganglioside, in the…

Continue

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